Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 5/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189555 | 0.80 | TDP2 (0.42) | TDP2PGRAHRCMA1GRM5 | |
| SCHEMBL25899774 | 0.80 | AHR (0.45) | TDP2PGRAHRCMA1GRM5 | |
| SCHEMBL20094336 | 0.76 | TDP2 (0.34) | TDP2PGRAHRCMA1GRM5 | |
| SCHEMBL20106765 | 0.74 | AHR (0.53) | TDP2PGRAHRCMA1GRM5 | |
| SCHEMBL20106766 | 0.74 | TDP2 (0.46) | TDP2AHRCMA1PDK2EIF2AK2 | |
| SCHEMBL2075401 | 0.72 | AHR (0.56) | TDP2PGRAHRCMA1GRM5 | |
| SCHEMBL20106900 | 0.71 | TDP2 (0.44) | TDP2AHRCMA1PDK2EIF2AK2 | |
| SCHEMBL20106978 | 0.70 | TDP2 (0.42) | TDP2AHREIF2AK2 | |
| SCHEMBL31116841 | 0.67 | PDE3B (0.52) | KDM4ENPSR1ALDH1A1 | |
| SCHEMBL5365648 | 0.67 | AHR (0.49) | TDP2PGRAHRCMA1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532477-B1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-26 | — | — | EP | disclosed |
| WO-2018080917-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |