Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 5/20 | 0.44 |
| ▸ | AHR | P35869 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP9 | P55211 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368226 | 0.81 | AHR (0.36) | TDP2AHRMEN1LMNAMAPT | |
| SCHEMBL18210365 | 0.79 | AHR (0.39) | TDP2AHRMEN1LMNAMAPT | |
| SCHEMBL20106766 | 0.79 | TDP2 (0.46) | TDP2AHRCMA1PDK2GRIA1 | |
| SCHEMBL20094337 | 0.77 | TDP2 (0.36) | TDP2AHRMEN1LMNAMAPT | |
| SCHEMBL20112858 | 0.75 | TDP2 (0.46) | TDP2AHRCMA1PDK2GRIA1 | |
| SCHEMBL20106765 | 0.75 | AHR (0.53) | TDP2AHRMEN1MAPTKMT2A | |
| SCHEMBL20106978 | 0.75 | TDP2 (0.42) | TDP2AHRMEN1MAPTKMT2A | |
| SCHEMBL12462776 | 0.71 | AHR (0.58) | TDP2AHRMEN1LMNAMAPT | |
| SCHEMBL20106904 | 0.71 | TDP2 (0.42) | TDP2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL20106901 | 0.71 | TDP2 (0.42) | TDP2AHRCMA1PDK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532477-B1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-26 | — | — | EP | disclosed |
| WO-2018080917-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |