Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20106903 | 0.81 | TDP2 (0.40) | TDP2MEN1KMT2AL3MBTL1PLK1 | |
| SCHEMBL20094339 | 0.78 | TDP2 (0.37) | TDP2MEN1KMT2AL3MBTL1CYP3A4 | |
| SCHEMBL20106766 | 0.77 | TDP2 (0.46) | TDP2AHRGRIA1CACNG8EIF2AK2 | |
| SCHEMBL18031225 | 0.76 | CA12 (0.49) | TDP2KMT2A | |
| SCHEMBL18031227 | 0.75 | MAPT (0.41) | MEN1KMT2AL3MBTL1CYP3A4MAPT | |
| SCHEMBL6028965 | 0.75 | KMT2A (0.42) | TDP2MEN1KMT2AL3MBTL1CYP3A4 | |
| SCHEMBL20106900 | 0.75 | TDP2 (0.44) | TDP2MEN1KMT2AMAPTAHR | |
| SCHEMBL20112858 | 0.74 | TDP2 (0.46) | TDP2AHRGRIA1CACNG8EIF2AK2 | |
| SCHEMBL20106765 | 0.74 | AHR (0.53) | TDP2MEN1KMT2AMAPTAHR | |
| SCHEMBL1317350 | 0.72 | AHR (0.56) | TDP2KMT2AL3MBTL1MAPTAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532477-B1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-26 | — | — | EP | disclosed |
| WO-2018080917-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |