Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088561 | 0.89 | PDE10A (0.38) | HAVCR2PDE10AHRH4 | |
| SCHEMBL20106759 | 0.85 | KDM4E (0.34) | — | |
| SCHEMBL20106737 | 0.80 | PDE10A (0.37) | PDE10A | |
| SCHEMBL20088555 | 0.75 | KDM4E (0.36) | PDE10A | |
| SCHEMBL20094307 | 0.72 | PDE10A (0.38) | PDE10A | |
| SCHEMBL20094632 | 0.72 | HTT (0.33) | — | |
| SCHEMBL20088546 | 0.70 | PDE10A (0.42) | PDE10A | |
| SCHEMBL20094619 | 0.70 | PTGES (0.32) | PDE10A | |
| SCHEMBL20094345 | 0.70 | TSHR (0.37) | PDE10AHRH4 | |
| SCHEMBL20106881 | 0.69 | ALDH1A1 (0.37) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018080917-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |