Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 9/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 5/20 | 0.37 |
| ▸ | CMA1 | P23946 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP9 | P55211 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318667 | 0.81 | TGM2 (0.44) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL1163094 | 0.78 | GRIA1 (0.41) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL4297627 | 0.78 | TDP2 (0.46) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL20106765 | 0.78 | AHR (0.53) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL5498437 | 0.78 | GRIA1 (0.41) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL20106766 | 0.78 | TDP2 (0.46) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL20106904 | 0.77 | TDP2 (0.42) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL20106900 | 0.75 | TDP2 (0.44) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL23612469 | 0.74 | GRIA1 (0.39) | TDP2GRIA1CACNG8AHRCMA1 | |
| SCHEMBL12056350 | 0.74 | GRIA1 (0.41) | TDP2GRIA1CACNG8AHRCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | disclosed |
| WO-2018080916-A1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |