SCHEMBL20107357

SCHEMBL20107357

BC(=O)C1(C(=O)OCC)CC1C(F)F

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.31
OPRM1 P35372 1/20 0.31
OPRD1 P41143 1/20 0.31
OPRK1 P41145 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18358208 0.90 POLB (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL19558558 0.90 POLB (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL18358211 0.90 POLB (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL18358200 0.85 OPRM1 (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL19558559 0.85 OPRM1 (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL20107144 0.85 OPRM1 (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL18358210 0.85 OPRM1 (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL18358230 0.85 OPRM1 (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL18358221 0.85 OPRM1 (0.34) POLBOPRM1OPRD1OPRK1MAPK1
SCHEMBL20467778 0.83 MAPK1 (0.33) POLBOPRM1OPRD1OPRK1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3315497-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING CYCLOPROPANE CARBOXYLIC ACID COMPOUND Central Glass Co., Ltd. (JP) 2018-05-02 EP disclosed