SCHEMBL20107468

SCHEMBL20107468

CC#CCOC(=O)c1cc(N)cc(N)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.45
MMP1 P03956 1/20 0.45
MMP2 P08253 1/20 0.45
MMP9 P14780 1/20 0.45
MMP12 P39900 1/20 0.45
CYP1A2 P05177 3/20 0.41
LMNA P02545 2/20 0.41
CYP3A4 P08684 2/20 0.41
MAOA P21397 2/20 0.41
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
CA12 O43570 2/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA9 Q16790 2/20 0.38
CA14 Q9ULX7 2/20 0.38
CA7 P43166 1/20 0.38
TSHR P16473 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13023149 0.83 NPC1 (0.47) NPC1MMP1MMP2MMP9MMP12
SCHEMBL3806695 0.81 MMP1 (0.54) NPC1MMP1MMP2MMP9MMP12
SCHEMBL20107471 0.80 CA12 (0.53) NPC1CYP1A2LMNACYP3A4MAOA
SCHEMBL1278720 0.77 NPC1 (0.68) NPC1CYP1A2LMNACYP3A4MAOA
SCHEMBL576103 0.76 LMNA (0.55) NPC1MMP1MMP2MMP9MMP12
SCHEMBL13023144 0.76 CA12 (0.53) NPC1CYP1A2LMNACYP3A4MAOA
Benzene SCHEMBL28861687 0.76 LMNA (0.55) NPC1MMP1MMP2MMP9MMP12
Hydrochloric Acid SCHEMBL9156219 0.76 NPC1 (0.66) NPC1CYP1A2LMNACYP3A4MAOA
SCHEMBL23343668 0.75 ALDH1A1 (0.51) NPC1MMP1MMP2MMP9MMP12
SCHEMBL29649183 0.75 NPC1 (0.60) NPC1CYP1A2LMNACYP3A4MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200262978-A1 Polyimides FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. 2020-08-20 US disclosed
WO-2018080870-A1 POLYIMIDES FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2018-05-03 WO disclosed