Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003398 | 0.83 | LMNA (0.55) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2005143 | 0.82 | AHR (0.74) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2012914 | 0.82 | LMNA (0.56) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2005107 | 0.81 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2005436 | 0.81 | LMNA (0.48) | LMNAALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2007187 | 0.81 | LMNA (0.55) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2003979 | 0.80 | AHR (0.53) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2006648 | 0.80 | LMNA (0.53) | THRBLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2004801 | 0.80 | LMNA (0.47) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2003315 | 0.80 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |