SCHEMBL2010849

SCHEMBL2010849

O=Nc1ccccc1-c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.48
SENP8 Q96LD8 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
SIGMAR1 Q99720 2/20 0.43
ALDH1A1 P00352 5/20 0.42
HSD17B10 Q99714 2/20 0.42
HPGD P15428 1/20 0.42
BCL2L1 Q07817 1/20 0.42
CYP2A6 P11509 1/20 0.42
MAPK1 P28482 1/20 0.42
HDAC4 P56524 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
NPC1 O15118 1/20 0.40
MAPT P10636 1/20 0.40
RAB9A P51151 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29690092 1.00 CASP3 (0.48) CASP3SENP8SENP7SENP6SIGMAR1
SCHEMBL13674376 0.82 KMT2A (0.41) CASP3SENP8SENP7SENP6ALDH1A1
SCHEMBL18619366 0.82 ALDH1A1 (0.44) CASP3SENP8SENP7SENP6ALDH1A1
SCHEMBL14303687 0.82 ABL1 (0.50) CASP3SENP8SENP7SENP6ALDH1A1
SCHEMBL7190436 0.82 NOTUM (0.44) ALDH1A1HSD17B10MAPK1NPC1MAPT
SCHEMBL3278999 0.81 HDAC4 (0.53) CASP3SENP8SENP7SENP6SIGMAR1
SCHEMBL13479270 0.81 KAT6A (0.38) CASP3SENP8SENP7SENP6SIGMAR1
SCHEMBL1232121 0.79 CASP3 (0.52) CASP3SENP8SENP7SENP6SIGMAR1
SCHEMBL3999159 0.79 CASP3 (0.71) CASP3SENP8SENP7SENP6SIGMAR1
SCHEMBL3266654 0.79 CASP3 (0.71) CASP3SENP8SENP7SENP6SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104910561-A Regenerated rubber sealing ring LIANG SHENGGUANG 2015-09-16 CN claimed
CN-103642090-A High-temperature resistant tread rubber used for car semi-steel radial tyres SHANDONG YONGTAI CHEMICAL CO 2014-03-19 CN claimed
EP-0403797-A2 The use of a light stabilizer comprising an aryl nitrogen compound for stabilizing an organic dye TAIYO YUDEN CO., LTD. (JP) 1990-12-27 EP claimed
EP-3164446-B1 UV-ACTIVE CHROMOPHORE FUNCTIONALIZED POLYILOXANES AND COPOLYMERS MADE THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2019-11-20 EP disclosed
CN-109789903-A rubber track 株式会社普利司通 2019-05-21 CN disclosed
CN-109134910-A The ethylene propylene diene rubber automotive hose and preparation method of a kind of high temperature resistant, oil resistant 成都市水泷头化工科技有限公司 2019-01-04 CN disclosed
EP-2841487-B1 POLY(PHENYLENE ETHER) COPOLYMER AND METHOD OF MAKING SABIC GLOBAL TECHNOLOGIES BV (NL) 2018-04-25 EP disclosed
CN-107922538-A It is used to prepare the polymerization of polyvinyls 陶氏环球技术有限责任公司 2018-04-17 CN disclosed
US-9896447-B2 TrkA kinase inhibitors, compositions and methods thereof MERCK SHARP & DOHME CORP. (US) 2018-02-20 US disclosed
US-9896447-B2 TrkA kinase inhibitors, compositions and methods thereof MERCK SHARP & DOHME CORP. (US) 2018-02-20 US disclosed
CN-107383476-A A kind of rubber-plastic foamed insulation material of shock-absorbing type and preparation method thereof 浙江中泰绝热材料有限公司 2017-11-24 CN disclosed
CN-101910313-A Aramid particles containing peroxide radical initiator TEIJIN ARAMID BV 2010-12-08 CN disclosed
CN-101287789-A Process for preparing vulcanized rubber mixtures STICHTING DUTCH POLYMER INST (NL) 2008-10-15 CN disclosed
CN-101120135-A Method for enhancing rubber properties by using Bunte salt-treated fiber TEIJIN TWARON BV (NL) 2008-02-06 CN disclosed
CN-1288220-C High strong adhesive and method for preparing same MO WANQUAN (CN) 2006-12-06 CN disclosed
US-7060830-B2 Synthesized γ-carbolines GEORGE MASON INTELLECTUAL PROPERTIES, INC. (US) 2006-06-13 US disclosed
CN-1654577-A High strong adhesive and method for preparing same MO WANQUAN (CN) 2005-08-17 CN disclosed
US-20050131010-A1 Synthesized gamma-carbolines WYNNE JAMES H (US) 2005-06-16 US disclosed
US-6872830-B1 Synthesized γ-carbolines GEORGE MASON UNIVERSITY (US) 2005-03-29 US disclosed
CN-1071937-A Tire and adhesive tape compositions AKZO NV (NL) 1993-05-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050131010-A1 Synthesized gamma-carbolines SNCA, PARK7, PRNP CASP3 500/4885SENP8 3868/4885SENP7 1981/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.