Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631379 | 1.00 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL2013818 | 0.88 | ALDH1A1 (0.47) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL12631691 | 0.88 | ALDH1A1 (0.47) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL12631617 | 0.87 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL12631381 | 0.87 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL2052998 | 0.87 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL2010182 | 0.86 | KMT2A (0.42) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL12631689 | 0.86 | KMT2A (0.42) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL12631378 | 0.85 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL12631681 | 0.84 | ALDH1A1 (0.47) | LMNASMN1; SMN2ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | claimed |