SCHEMBL2010904

SCHEMBL2010904

CCCc1ccc(N(C)C(=O)O)cc1N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.37
CFTR P13569 1/20 0.36
PRKCI P41743 1/20 0.34
PTPN1 P18031 1/20 0.34
PTPN11 Q06124 1/20 0.34
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
THRB P10828 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
GFER P55789 1/20 0.33
PLEC Q15149 1/20 0.33
PDK1 Q15118 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31
GABRA1 P14867 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27675193 0.90 GABRP (0.34) MCHR1KDM4EALDH1A1GAAMAPT
SCHEMBL398694 0.80 BRD4 (0.38) MCHR1CFTRPRKCIKDM4EMAPT
SCHEMBL22897721 0.80 ALDH1A1 (0.40) CFTRALDH1A1GFERS100B
SCHEMBL27797704 0.78 CYP1A2 (0.42) ALDH1A1MAPTPDK1
SCHEMBL6179410 0.73 GAA (0.58) KDM4EALDH1A1GAAMAPTTHRB
SCHEMBL2858939 0.73 ALDH1A1 (0.35) KDM4EALDH1A1GAAMAPTGFER
SCHEMBL11723702 0.71 S100B (0.50) KDM4EALDH1A1GAAMAPTTHRB
SCHEMBL4015584 0.71 ALDH1A1 (0.50) KDM4EALDH1A1GAAMAPTHPGD
SCHEMBL27693776 0.71 KDM4E (0.36) CFTRKDM4EALDH1A1MAPTGABRA1
SCHEMBL21586818 0.70 HDAC1 (0.42) KDM4EALDH1A1GAAMAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104788328-A Modulators of ATP-binding cassette transporters VERTEX PHARMA 2015-07-22 CN disclosed
EP-2509954-A1 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2012-10-17 EP disclosed
WO-2011072241-A1 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-06-16 WO disclosed
CN-101935301-A Modulators of ATP-binding cassette transporters VERTEX PHARMA 2011-01-05 CN disclosed
CN-101891680-A The adjusting control agent of ATP- combination cassette transporters VERTEX PHARMA 2010-11-24 CN disclosed
EP-1773816-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2007-04-18 EP disclosed
WO-2006002421-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2006-01-05 WO disclosed