Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 9/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142238 | 0.82 | ALDH1A1 (0.65) | ALDH1A1CYP1A2POLBCNR2HTT | |
| SCHEMBL15273185 | 0.81 | AKR1C3 (0.39) | ALDH1A1CYP1A2POLBCNR2HTT | |
| SCHEMBL11965202 | 0.79 | MCL1 (0.67) | MEN1KMT2AMCL1SLC9A1 | |
| SCHEMBL4215637 | 0.78 | KDM4E (0.70) | ALDH1A1CYP1A2POLBCNR2MEN1 | |
| SCHEMBL6752507 | 0.72 | ALDH1A1 (0.64) | ALDH1A1CYP1A2POLBCNR2HTT | |
| SCHEMBL14334586 | 0.72 | TP53 (0.56) | ALDH1A1CYP1A2POLBHTTMEN1 | |
| SCHEMBL29359024 | 0.72 | TP53 (0.56) | ALDH1A1CYP1A2POLBHTTMEN1 | |
| SCHEMBL13742238 | 0.70 | ALDH1A1 (0.65) | ALDH1A1CYP1A2POLBCNR2HTT | |
| SCHEMBL700800 | 0.70 | ALDH1A1 (0.69) | ALDH1A1CYP1A2POLBCNR2HTT | |
| SCHEMBL13305894 | 0.69 | CCR2 (0.69) | ALDH1A1CYP1A2POLBKMT2AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180117041-A1 | LIVER X RECEPTOR MODULATORS | VITAE PHARMACEUTICALS, INC. | 2018-05-03 | — | — | US | disclosed |
| US-20180117041-A1 | LIVER X RECEPTOR MODULATORS | VITAE PHARMACEUTICALS, INC. | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180117041-A1 | LIVER X RECEPTOR MODULATORS | SLC10A1, NR1H4, NR1H2 | ALDH1A1 882/4885CYP1A2 117/4885POLB 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.