Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577937 | 0.81 | METAP2 (0.39) | NOS1LRRK2ADORA2ATRPA1FGFR1 | |
| SCHEMBL766959 | 0.76 | NOS1 (0.46) | NOS1LRRK2ADORA2ATRPA1FGFR1 | |
| SCHEMBL3515094 | 0.76 | MAPT (0.46) | NOS1LRRK2ADORA2AMAPKAPK2TRPA1 | |
| SCHEMBL19204828 | 0.76 | LRRK2 (0.40) | NOS1LRRK2ADORA2ATRPA1FGFR1 | |
| SCHEMBL18107535 | 0.76 | FGFR1 (0.44) | NOS1LRRK2ADORA2ATRPA1FGFR1 | |
| SCHEMBL19204860 | 0.76 | NOS1 (0.46) | NOS1LRRK2ADORA2ATRPA1FGFR1 | |
| SCHEMBL15759797 | 0.76 | NOS1 (0.46) | NOS1MAPKAPK2TRPA1FGFR1MAPT | |
| SCHEMBL30099420 | 0.76 | NOS1 (0.50) | NOS1MAPKAPK2FGFR1FGFR2METAP2 | |
| SCHEMBL20106902 | 0.76 | RXRA (0.47) | NOS1ADORA2ATRPA1METAP2 | |
| SCHEMBL20085784 | 0.72 | SLC2A1 (0.37) | NOS1LRRK2ADORA2ATRPA1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | disclosed |
| WO-2018080916-A1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |