Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014620 | 0.89 | ALDH1A1 (0.66) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2978081 | 0.84 | AR (0.58) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL29979942 | 0.84 | AR (0.58) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL12631069 | 0.83 | MEN1 (0.53) | KMT2AMEN1ALDH1A1MAPTPOLB | |
| SCHEMBL30669432 | 0.83 | AR (0.57) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8570002 | 0.83 | AR (0.57) | ARPELP1KMT2AALDH1A1MAPT | |
| SCHEMBL10318922 | 0.83 | AR (0.57) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2013821 | 0.82 | AR (0.58) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL221362 | 0.81 | AR (0.61) | ARPELP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4288702 | 0.80 | AR (0.57) | ARPELP1KMT2AALDH1A1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |