Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013298 | 0.87 | ALDH1A1 (0.71) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL2011302 | 0.83 | AR (0.53) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL23589263 | 0.80 | PTGDR2 (0.54) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL10197528 | 0.79 | NPC1 (0.49) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL29024321 | 0.77 | CYP11B1 (0.49) | MAPTNPC1MAPK1RAB9A | |
| SCHEMBL12631070 | 0.77 | L3MBTL1 (0.40) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL10197531 | 0.76 | NPC1 (0.46) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL1990199 | 0.75 | MAPK1 (0.46) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL6327826 | 0.74 | ALDH1A1 (0.71) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL23589335 | 0.74 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |