Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 16/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16635325 | 0.88 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL20113241 | 0.81 | TRPA1 (0.77) | TRPA1 | |
| SCHEMBL893990 | 0.79 | TSHR (0.61) | TRPA1TSHRATM | |
| SCHEMBL21442122 | 0.77 | TRPA1 (0.68) | TRPA1 | |
| SCHEMBL16635446 | 0.77 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL10164533 | 0.76 | L3MBTL1 (0.56) | TRPA1TSHRATM | |
| SCHEMBL20113086 | 0.76 | TRPA1 (0.78) | TRPA1TSHRATM | |
| SCHEMBL21441950 | 0.76 | TRPA1 (0.63) | TRPA1TSHRATM | |
| SCHEMBL10164494 | 0.76 | L3MBTL1 (0.55) | TRPA1TSHRATM | |
| SCHEMBL10164523 | 0.76 | L3MBTL1 (0.55) | TRPA1TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118680-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | GENENTECH, INC. (US) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118680-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885TSHR 3100/4885ATM 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.