Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 3/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113756 | 0.89 | CCR1 (0.41) | CCR1ALDH1A1 | |
| SCHEMBL1260062 | 0.76 | TYR (0.41) | CCR1CTRCTYRTLR8ALDH1A1 | |
| SCHEMBL22546299 | 0.71 | KCNH2 (0.53) | CTRCTYRTLR8TDP1MEN1 | |
| SCHEMBL28207251 | 0.71 | TYR (0.38) | CTRCTYRTLR8ALDH1A1HPGD | |
| SCHEMBL7092724 | 0.70 | KCNH2 (0.56) | CCR1HIF1AEPAS1TDP1GAA | |
| SCHEMBL27813430 | 0.69 | TYR (0.47) | TYRTLR8HIF1AALDH1A1HPGD | |
| SCHEMBL11728240 | 0.69 | KCNH2 (0.55) | TYRTLR8ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL29955867 | 0.69 | ALDH1A1 (0.35) | CCR1TLR8HIF1AEPAS1ALDH1A1 | |
| SCHEMBL19304402 | 0.69 | KDM4E (0.39) | CTRCTYRTLR8 | |
| SCHEMBL6629423 | 0.69 | CCR1 (0.50) | CCR1ALDH1A1MAPTTSHRNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |