Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113653 | 0.89 | CCR1 (0.38) | CCR1ALDH1A1 | |
| SCHEMBL2411392 | 0.77 | CCR1 (0.37) | CCR1ALDH1A1CTSLCTSSCTSK | |
| SCHEMBL14868199 | 0.74 | PDE10A (0.41) | CCR1ALDH1A1PRKCICA12GRM1 | |
| SCHEMBL6629423 | 0.71 | CCR1 (0.50) | CCR1ALDH1A1 | |
| SCHEMBL24755263 | 0.71 | NOS2 (0.50) | ALDH1A1 | |
| SCHEMBL10282395 | 0.71 | ALDH1A1 (0.35) | ALDH1A1PRKCI | |
| SCHEMBL19018366 | 0.70 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL20114317 | 0.70 | S1PR4 (0.44) | CCR1ALDH1A1 | |
| SCHEMBL25821245 | 0.70 | ALDH3A1 (0.46) | CCR1ALDH1A1 | |
| SCHEMBL20113637 | 0.69 | GRM1 (0.32) | GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |