Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 20/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27052092 | 0.73 | FGFR4 (0.56) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL22079449 | 0.71 | FGFR4 (0.50) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL22079474 | 0.70 | FGFR4 (0.53) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL20113649 | 0.70 | MEN1 (0.37) | — | |
| SCHEMBL27052551 | 0.70 | FGFR4 (0.45) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL28394855 | 0.70 | FGFR4 (0.44) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL29569300 | 0.69 | FGFR4 (0.60) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL20113637 | 0.68 | GRM1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL29802288 | 0.68 | FGFR4 (0.59) | FGFR4AURKAMAPKAPK2 | |
| SCHEMBL22079452 | 0.68 | FGFR4 (0.49) | FGFR4AURKAMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |