Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113675 | 0.84 | ALDH1A1 (0.34) | GRM1 | |
| SCHEMBL20113671 | 0.83 | GLP1R (0.33) | GRM1 | |
| SCHEMBL20113649 | 0.81 | MEN1 (0.37) | GRM1 | |
| SCHEMBL20113662 | 0.77 | — | — | |
| SCHEMBL17408855 | 0.74 | BCHE (0.37) | KCNJ1NOS3NOS1NOS2 | |
| SCHEMBL20113696 | 0.72 | MEN1 (0.36) | NOS2 | |
| SCHEMBL9846251 | 0.70 | GRM1 (0.37) | GRM1 | |
| SCHEMBL24771606 | 0.69 | LMNA (0.34) | KCNJ1 | |
| SCHEMBL30786784 | 0.69 | LMNA (0.34) | KCNJ1 | |
| SCHEMBL20113706 | 0.69 | FGFR4 (0.35) | GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |