Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | PDXK | O00764 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113696 | 0.91 | MEN1 (0.36) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL20113637 | 0.81 | GRM1 (0.32) | GRM1 | |
| SCHEMBL20113675 | 0.80 | ALDH1A1 (0.34) | ALDH1A1LMNAGRM1 | |
| SCHEMBL20113671 | 0.79 | GLP1R (0.33) | ALDH1A1HPGDGRM1 | |
| SCHEMBL20113662 | 0.73 | — | — | |
| SCHEMBL20113995 | 0.71 | FGFR4 (0.35) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL20113643 | 0.71 | KDM4E (0.37) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL20113669 | 0.70 | FGFR4 (0.40) | — | |
| SCHEMBL20113706 | 0.69 | FGFR4 (0.35) | GRM1 | |
| SCHEMBL4167074 | 0.68 | MEN1 (0.52) | MEN1KMT2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |