Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | SMO | Q99835 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676389 | 0.86 | ALDH1A1 (0.55) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| SCHEMBL20676691 | 0.86 | HTT (0.57) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| SCHEMBL20676557 | 0.84 | RAB9A (0.61) | TSHRL3MBTL1MAPK1ALDH1A1GAA | |
| SCHEMBL26996429 | 0.84 | TLR9 (0.55) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| SCHEMBL20676390 | 0.83 | TLR9 (0.70) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| SCHEMBL20676371 | 0.82 | LMNA (0.46) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| SCHEMBL20116204 | 0.82 | HTT (0.58) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| SCHEMBL21611298 | 0.81 | LMNA (0.47) | TSHRHTTMEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL30506238 | 0.81 | HTT (0.58) | TSHRHTTMEN1CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL20660764 | 0.81 | HTT (0.58) | TSHRHTTMEN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |