Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116824 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNATSHRALDH1A1POLB | |
| SCHEMBL20116852 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNATSHRALDH1A1MAPT | |
| SCHEMBL20117283 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNATSHRALDH1A1MAPT | |
| SCHEMBL20676469 | 0.82 | HSD11B1 (0.49) | SMN1; SMN2LMNATSHRALDH1A1CYP3A4 | |
| SCHEMBL20117119 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNATSHRALDH1A1HTT | |
| SCHEMBL20116410 | 0.75 | LMNA (0.49) | SMN1; SMN2LMNATSHRALDH1A1POLB | |
| SCHEMBL20116500 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNATSHRALDH1A1HTT | |
| SCHEMBL20116455 | 0.73 | LMNA (0.44) | SMN1; SMN2LMNATSHRHTTALOX15 | |
| SCHEMBL22357945 | 0.73 | LMNA (0.45) | SMN1; SMN2LMNATSHRALDH1A1POLB | |
| SCHEMBL20676430 | 0.72 | LMNA (0.41) | SMN1; SMN2LMNATSHRHTTTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |