Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116852 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20676469 | 0.84 | HSD11B1 (0.49) | SMN1; SMN2LMNATSHRHTTALDH1A1 | |
| SCHEMBL20116730 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNATSHRHTTALDH1A1 | |
| SCHEMBL20116824 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNATSHRHTTGAA | |
| SCHEMBL20116634 | 0.73 | TSHR (0.58) | SMN1; SMN2LMNATSHRHTTNPC1 | |
| SCHEMBL21611298 | 0.73 | LMNA (0.47) | SMN1; SMN2LMNATSHRHTTNPC1 | |
| SCHEMBL20116857 | 0.73 | HTT (0.42) | SMN1; SMN2LMNATSHRHTTNPC1 | |
| SCHEMBL20116798 | 0.72 | KIT (0.42) | SMN1; SMN2LMNATSHRHTTNPC1 | |
| SCHEMBL20116749 | 0.72 | NR1H4 (0.45) | SMN1; SMN2LMNATSHRHTTNPC1 | |
| SCHEMBL20116815 | 0.71 | CNR2 (0.47) | SMN1; SMN2LMNATSHRHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |