SCHEMBL2011679

SCHEMBL2011679

Nc1cc2ccccc2nc1[N+](=O)[O-]

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.50
RAB9A P51151 4/20 0.50
MEN1 O00255 4/20 0.50
ALDH1A1 P00352 6/20 0.49
NPC1 O15118 4/20 0.44
POLB P06746 3/20 0.44
GLA P06280 2/20 0.44
HPGD P15428 2/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
PTBP1 P26599 1/20 0.44
RCE1 Q9Y256 1/20 0.44
MAPT P10636 4/20 0.43
ACHE P22303 1/20 0.43
HTR3A P46098 1/20 0.42
HTT P42858 1/20 0.42
ATM Q13315 1/20 0.42
IKBKB O14920 1/20 0.41
CYP1A2 P05177 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1682777 0.84 RAB9A (0.55) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL14179218 0.79 TDP1 (0.50) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL10339542 0.79 RAB9A (0.50) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL2011678 0.79 RAB9A (0.54) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL14842175 0.79 ALDH1A1 (0.49) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL11667039 0.76 MAPT (0.48) KMT2ARAB9AMEN1ALDH1A1NPC1
Acridine SCHEMBL27545385 0.76 RAB9A (0.63) KMT2ARAB9AMEN1ALDH1A1NPC1
Acridine SCHEMBL28471035 0.75 ALDH1A1 (0.65) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL2230214 0.75 TLR8 (0.54) KMT2ARAB9AMEN1ALDH1A1NPC1
SCHEMBL7468366 0.75 HTT (0.48) KMT2ARAB9AMEN1ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2755982-A1 SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES Merck Sharp & Dohme Corp. (US) 2014-07-23 EP disclosed
WO-2013039878-A1 SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2013-03-21 WO disclosed
EP-2545060-A1 FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES Merck Sharp & Dohme Corp. (US) 2013-01-16 EP disclosed
EP-2516430-A1 FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES Merck Sharp & Dohme Corp. (US) 2012-10-31 EP disclosed
EP-2503881-A1 FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES Merck Sharp & Dohme Corp. (US) 2012-10-03 EP disclosed
WO-2011112429-A1 FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES SCHERING CORPORATION (US) 2011-09-15 WO disclosed
WO-2011087740-A1 FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES SCHERING CORPORATION (US) 2011-07-21 WO disclosed
WO-2011066241-A1 FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES SCHERING CORPORATION (US) 2011-06-03 WO disclosed
EP-0735025-B1 Process for producing aminonitropyridines SUMITOMO CHEMICAL CO (JP) 1998-07-01 EP disclosed
US-5648496-A AMINATION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-15 US disclosed
EP-0735025-A1 Process for producing aminonitropyridines SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-02 EP disclosed