SCHEMBL20117601

SCHEMBL20117601

CCc1ccc2c(c1F)-c1c-2cc(OCC2CCC(C)CC2)c(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 5/20 0.36
HPGD P15428 3/20 0.35
RIPK1 Q13546 1/20 0.33
BRD4 O60885 2/20 0.32
PDE10A Q9Y233 1/20 0.32
HTR2A P28223 2/20 0.32
HTR2C P28335 2/20 0.32
HTR2B P41595 2/20 0.32
GRM2 Q14416 1/20 0.32
KDM5A P29375 1/20 0.32
KDM4C Q9H3R0 1/20 0.32
PDE4D Q08499 2/20 0.31
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
ROCK2 O75116 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20117803 0.97 SCN9A (0.35) SCN9AHPGDRIPK1BRD4PDE10A
SCHEMBL20102456 0.89 RIPK1 (0.35) RIPK1BRD4PDE10AHTR2AHTR2C
SCHEMBL20111296 0.87 CYP19A1 (0.32) SCN9ARIPK1BRD4HTR2AHTR2C
SCHEMBL20111270 0.87 HPGD (0.36) SCN9AHPGDBRD4HTR2AHTR2C
SCHEMBL20111285 0.87 HPGD (0.36) SCN9AHPGDBRD4HTR2AHTR2C
SCHEMBL20117739 0.86 HPGD (0.36) SCN9AHPGDRIPK1GRM2
SCHEMBL20111240 0.85 SCN9A (0.35) SCN9AHPGDRIPK1BRD4PDE10A
SCHEMBL20117747 0.84 HPGD (0.36) SCN9AHPGDRIPK1BRD4HTR2A
SCHEMBL20102545 0.84 RIPK1 (0.32) RIPK1
SCHEMBL20117669 0.83 SCN9A (0.43) SCN9AHPGDHTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3315583-A1 LIQUID CRYSTAL COMPOUND HAVING BIPHENYLENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-05-02 EP disclosed