Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245177 | 0.88 | MAPT (0.52) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL245779 | 0.86 | MAPT (0.50) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL6681971 | 0.83 | MAPT (0.56) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL2237474 | 0.81 | MAPT (0.52) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL25402190 | 0.81 | RXFP1 (0.46) | MAPTSMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL29949243 | 0.81 | CTSL (0.41) | MAPTSMN1; SMN2ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL244443 | 0.80 | MAPT (0.56) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL246643 | 0.79 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL245442 | 0.78 | MAPT (0.43) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL17771216 | 0.78 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2RAB9ANPC1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-B1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | PIMCO 2664 LTD (GB) | 2018-05-02 | — | — | EP | disclosed |