Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245178 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL245779 | 0.84 | MAPT (0.50) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL245177 | 0.81 | MAPT (0.52) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL246563 | 0.81 | CTSB (0.43) | SMN1; SMN2NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL20117837 | 0.79 | MAPT (0.50) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL6681971 | 0.78 | MAPT (0.56) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL1019102 | 0.77 | MAPT (0.55) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL15584492 | 0.76 | MAPT (0.47) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL3064038 | 0.75 | ALDH1A1 (0.54) | SMN1; SMN2MAPTNPC1RAB9AALOX5 | |
| SCHEMBL244443 | 0.75 | MAPT (0.56) | SMN1; SMN2MAPTNPC1RAB9AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585440-A1 | 3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATEMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA | Janssen Pharmaceutica, N.V. (BE) | 2013-05-01 | — | — | EP | disclosed |
| WO-2012000933-A1 | 3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATEMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-05 | — | — | WO | disclosed |