Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.39 |
| ▸ | LPL | P06858 | 7/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118981 | 0.85 | LIPG (0.43) | LIPGLPLP4HBIRAK4ROCK1 | |
| SCHEMBL18567448 | 0.77 | LIPG (0.41) | LIPGLPLP4HBIRAK4ROCK1 | |
| SCHEMBL20119475 | 0.77 | P4HB (0.37) | LIPGLPLP4HBROCK1HIF1A | |
| SCHEMBL25875321 | 0.73 | LIPG (0.52) | LIPGLPLP4HB | |
| SCHEMBL14760399 | 0.73 | LIPG (0.49) | LIPGLPLP4HBIRAK4ROCK1 | |
| SCHEMBL18586856 | 0.72 | LIPG (0.43) | LIPGLPLP4HBIRAK4ROCK1 | |
| SCHEMBL16397072 | 0.71 | P4HB (0.43) | LIPGLPLP4HBIRAK4ROCK1 | |
| SCHEMBL23031277 | 0.70 | LIPG (0.47) | LIPGLPLP4HBIRAK4ROCK1 | |
| SCHEMBL488896 | 0.70 | P4HB (0.50) | LIPGLPLP4HBROCK1ALDH1A1 | |
| SCHEMBL4782167 | 0.70 | P4HB (0.47) | LIPGLPLP4HBROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908824-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |