Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.36 |
| ▸ | LPL | P06858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397072 | 0.84 | P4HB (0.43) | P4HBLIPGLPLROCK1HIF1A | |
| SCHEMBL16397840 | 0.79 | AAK1 (0.46) | P4HBLIPGLPLHIF1AMAPT | |
| SCHEMBL18586856 | 0.78 | LIPG (0.43) | P4HBLIPGLPLROCK1HIF1A | |
| SCHEMBL1075476 | 0.78 | GAA (0.50) | GAAALDH1A1MAPTCA1CA2 | |
| SCHEMBL20118982 | 0.77 | LIPG (0.39) | P4HBLIPGLPLALDH1A1ROCK1 | |
| SCHEMBL1232115 | 0.75 | SMYD3 (0.50) | KDM4ESMN1; SMN2HPGD | |
| SCHEMBL553260 | 0.75 | LIPG (0.48) | LIPGLPLALDH1A1MAPTKDM4E | |
| SCHEMBL4782167 | 0.73 | P4HB (0.47) | P4HBLIPGLPLALDH1A1ROCK1 | |
| SCHEMBL488896 | 0.73 | P4HB (0.50) | P4HBLIPGLPLGAAALDH1A1 | |
| SCHEMBL30015761 | 0.73 | P4HB (0.50) | P4HBLIPGLPLGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908824-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |