Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178573 | 0.81 | MAPT (0.53) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL20173764 | 0.81 | CA2 (0.59) | KMT2AMEN1HTT | |
| SCHEMBL5184916 | 0.81 | LMNA (0.76) | TSHRSMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL4416620 | 0.80 | SMN1; SMN2 (0.77) | HSD17B10SMN1; SMN2KMT2APKMSAE1 | |
| SCHEMBL29703055 | 0.80 | SMN1; SMN2 (0.77) | HSD17B10SMN1; SMN2KMT2APKMSAE1 | |
| SCHEMBL2632867 | 0.79 | SAE1 (0.68) | HSD17B10SMN1; SMN2KMT2APKMSAE1 | |
| SCHEMBL14433200 | 0.77 | HPGD (0.61) | TSHRHSD17B10SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20118984 | 0.77 | NPC1 (0.57) | HSD17B10SMN1; SMN2KMT2APKMSAE1 | |
| SCHEMBL8625988 | 0.76 | LMNA (0.60) | TSHRHSD17B10KMT2ANPC1RAB9A | |
| SCHEMBL18025299 | 0.76 | POLB (0.63) | TSHRHSD17B10SMN1; SMN2KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081285-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |