Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855389 | 0.78 | CLK1 (0.51) | CDC7CLK1LIMK1DBF4 | |
| SCHEMBL24623703 | 0.76 | LIMK1 (0.39) | CDC7CLK1LIMK1DBF4 | |
| SCHEMBL22483133 | 0.75 | KDM4E (0.36) | CLK1LIMK1 | |
| SCHEMBL24623622 | 0.75 | KDM4E (0.36) | LIMK1 | |
| SCHEMBL24623999 | 0.75 | KDM4E (0.34) | CLK1LIMK1 | |
| SCHEMBL24624022 | 0.73 | — | — | |
| SCHEMBL25662800 | 0.72 | ALDH1A1 (0.54) | CDC7LIMK1DBF4 | |
| SCHEMBL22483136 | 0.70 | CYP2A6 (0.33) | CLK1LIMK1 | |
| SCHEMBL24623620 | 0.70 | CYP2A6 (0.35) | — | |
| SCHEMBL25461054 | 0.69 | CLK1 (0.32) | CLK1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558309-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | UNIV VANDERBILT (US) | 2023-07-26 | — | — | EP | disclosed |
| CN-109862893-B | Muscarinic acetylcholine receptor M 4 Positive allosteric modulators of | 范德比尔特大学 | 2023-02-17 | — | — | CN | disclosed |
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-10-31 | — | — | US | disclosed |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-10-31 | — | — | US | disclosed |
| EP-3558309-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-3558309-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018085808-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2018-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM2, CHRM4, CHRM5 | CDC7 3036/4885CLK1 3821/4885LIMK1 3744/4885 |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM2, CHRM4, CHRM5 | CDC7 3036/4885CLK1 3821/4885LIMK1 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.