Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010798 | 0.88 | ALDH1A1 (0.53) | LMNARAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL2012056 | 0.79 | LMNA (0.50) | LMNATP53L3MBTL1RAB9AALDH1A1 | |
| SCHEMBL19411773 | 0.74 | SMN1; SMN2 (0.54) | LMNARAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL7772483 | 0.72 | LMNA (0.70) | LMNARAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL5586755 | 0.71 | LDHA (0.51) | LMNAPPARGJUNRAB9AALDH1A1 | |
| SCHEMBL10462709 | 0.71 | LMNA (0.59) | LMNARAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL5589186 | 0.71 | LDHA (0.50) | LMNAPPARGJUNRAB9AALDH1A1 | |
| SCHEMBL2012539 | 0.70 | PDE3B (0.38) | LMNARAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL5589806 | 0.69 | LDHA (0.49) | PPARGJUNALDH1A1KDM4EHPGD | |
| SCHEMBL1127505 | 0.69 | RPA1 (0.54) | LMNAPPARGRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011072691-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |