SCHEMBL2012133

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2011936	0.94	ALDH1A1 (0.50)	BDKRB1ALDH1A1TSHRHPGDL3MBTL1
	SCHEMBL2013353	0.75	CACNA1G (0.45)	ALDH1A1TSHRHPGDL3MBTL1MEN1
	SCHEMBL2012284	0.73	EPHX2 (0.46)	ALDH1A1HPGDL3MBTL1EPHX2MEN1
	SCHEMBL2011927	0.72	ALDH1A1 (0.50)	ALDH1A1TSHRMEN1KMT2A
	SCHEMBL17335683	0.72	ALDH1A1 (0.61)	ALDH1A1TSHRHPGDTAS1R3TAS1R1
	SCHEMBL7445856	0.72	ALDH1A1 (0.61)	ALDH1A1TSHRHPGDTAS1R3TAS1R1
	SCHEMBL26779718	0.72	ALDH1A1 (0.61)	ALDH1A1TSHRHPGDTAS1R3TAS1R1
	SCHEMBL2013918	0.72	MAPT (0.40)	ALDH1A1KMT2A
	SCHEMBL2016657	0.71	MAPT (0.53)	ALDH1A1MEN1KMT2A
	SCHEMBL2012033	0.71	MAPT (0.36)	ALDH1A1TSHRKMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.