Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645824 | 0.89 | KDM4E (0.94) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL1019998 | 0.89 | KDM4E (0.94) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL30576832 | 0.87 | KDM4E (0.74) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL10076259 | 0.84 | KDM4E (0.74) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL13150665 | 0.84 | CASP1 (0.59) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL13149349 | 0.84 | KDM4E (0.78) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL4486386 | 0.84 | KDM4E (0.78) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL17695973 | 0.83 | ALDH1A1 (0.68) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL19562173 | 0.83 | KDM4E (0.68) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL25041158 | 0.82 | KDM4E (0.76) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963452-B2 | Methods, compounds, and compositions for inhibition of ROS | AUGUSTA PHARMACEUTICALS INC. (US) | 2018-05-08 | — | — | US | disclosed |