Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.72 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 8/20 | 0.55 |
| ▸ | NR0B2 | Q15466 | 3/20 | 0.55 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122013 | 0.86 | HDAC11 (0.61) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| SCHEMBL20122000 | 0.86 | RARB (0.56) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| SCHEMBL20018663 | 0.85 | PTPN11 (0.56) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| Adarotene SCHEMBL29449480 | 0.84 | RARB (1.00) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| Adarotene SCHEMBL403528 | 0.84 | RARB (1.00) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| Adarotene SCHEMBL403527 | 0.84 | RARB (1.00) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| Adarotene SCHEMBL29462720 | 0.84 | RARB (1.00) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| SCHEMBL8255190 | 0.79 | RARB (0.57) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| SCHEMBL25870575 | 0.76 | RARB (0.76) | RARBHDAC11HDAC2HDAC7HDAC8 | |
| SCHEMBL20018671 | 0.76 | HDAC11 (0.50) | RARBHDAC11HDAC2HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763715-A1 | HARRINGTONINES SALTS, IN PARTICULAR RETINOATES, THEIR PROCESS OF PREPARATION AND THEIR USES IN THE TREATMENT OF LEUKEMIAS, CANCERS, AUTOIMMUNE, SKIN, ALZHEIMER'S AND INFLAMMATORY BOWEL DISEASES AND VIRAL INFECTIONS, COMBINED WITH MYELOPOIESIS STIMULATING AGENTS | Robin, Jean-Pierre (CH) | 2021-01-13 | — | — | EP | disclosed |
| US-9963439-B2 | Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-05-08 | — | — | US | disclosed |