Adarotene

Adarotene

SCHEMBL403528

O=C(O)C=Cc1ccc(-c2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 6/20 1.00
HDAC11 Q96DB2 5/20 0.78
HDAC2 Q92769 2/20 0.78
HDAC7 Q8WUI4 2/20 0.78
HDAC8 Q9BY41 2/20 0.78
HDAC6 Q9UBN7 2/20 0.78
HDAC3 O15379 1/20 0.78
HDAC4 P56524 1/20 0.78
HDAC9 Q9UKV0 1/20 0.78
HDAC5 Q9UQL6 1/20 0.78
PTPN11 Q06124 6/20 0.74
NR0B2 Q15466 3/20 0.74
RARA P10276 3/20 0.62
RARG P13631 3/20 0.62
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
KDM4E B2RXH2 1/20 0.58
ALDH1A1 P00352 1/20 0.58
TP53 P04637 1/20 0.58
CYP3A4 P08684 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adarotene SCHEMBL29462720 1.00 RARB (1.00) RARBHDAC11HDAC2HDAC7HDAC8
Adarotene SCHEMBL403527 1.00 RARB (1.00) RARBHDAC11HDAC2HDAC7HDAC8
Adarotene SCHEMBL29449480 1.00 RARB (1.00) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL2405332 0.89 RARB (0.80) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL2389152 0.89 RARB (0.80) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL2389155 0.89 RARB (0.80) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL2405337 0.89 RARB (0.80) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL3295460 0.88 HDAC2 (1.00) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL3295457 0.88 HDAC2 (1.00) RARBHDAC11HDAC2HDAC7HDAC8
SCHEMBL25870575 0.86 RARB (0.76) RARBHDAC11HDAC2HDAC7HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160339106-A1 PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC (US) 2016-11-24 US claimed
EP-3016715-A1 PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY University Of Georgia Research Foundation, Inc. (US) 2016-05-11 EP claimed
WO-2015002996-A1 PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2015-01-08 WO claimed
US-20100330200-A1 COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2010-12-30 US claimed
WO-2010106135-A1 COMBINED USE FOR THE TREATMENT OF OVARIAN CARCINOMA SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2010-09-23 WO claimed
EP-2101820-A2 COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) 2009-09-23 EP claimed
WO-2008077772-A2 COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA (IT) 2008-07-03 WO claimed
US-20260035353-A1 PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE SPECIAL PRODUCTS LINE S P A (IT) 2026-02-05 US disclosed
EP-4661876-A1 METABOLIC INHIBITORS AND METHODS OF MAKING AND USING THEREOF University of Miami (US) 2025-12-17 EP disclosed
WO-2024168133-A1 METABOLIC INHIBITORS AND METHODS OF MAKING AND USING THEREOF UNIVERSITY OF MIAMI (US) 2024-08-15 WO disclosed
US-20240052418-A1 METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-02-15 US disclosed
US-11814681-B2 Method for predicting a subjects response to SLC modulator therapy THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-11-14 US disclosed
EP-3495349-B1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2023-06-28 EP disclosed
WO-2007056135-A1 METHOD OF TREATING CANCERS WITH SAHA AND PEMETREXED MERCK & CO., INC. (US) 2007-05-18 WO disclosed
WO-2007056162-A2 METHODS OF TREATING CANCERS WITH SAHA, CARBOPLATIN, AND PACLITAXEL AND OTHER COMBINATION THERAPIES MERCK & CO., INC. (US) 2007-05-18 WO disclosed
WO-2007056244-A2 METHODS OF USING SAHA AND ERLOTINIB FOR TREATING CANCER MERCK & CO., INC. (US) 2007-05-18 WO disclosed
WO-2007056232-A2 METHODS OF USING SAHA AND BORTEZOMIB FOR TREATING CANCER MERCK & CO., INC. (US) 2007-05-18 WO disclosed
WO-2007022408-A2 COMBINATION METHODS OF SAHA AND TARGRETIN FOR TREATING CANCER MERCK & CO., INC. (US) 2007-02-22 WO disclosed
WO-2007000383-A1 BIPHENYL AND NAPHTHYL-PHENYL HYDROXAMIC ACID DERIVATIVES SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2007-01-04 WO disclosed
US-20040235757-A1 Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2004-11-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035353-A1 PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE TLR7, GANC, ARG1 RARB 2413/4885HDAC11 1114/4885HDAC2 2388/4885
US-20040235757-A1 Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities RARA, RARB, RARG RARB 2/4885HDAC11 883/4885HDAC2 2621/4885
US-20160339106-A1 PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY SLC25A1, HADHA, CS RARB 1873/4885HDAC11 1522/4885HDAC2 756/4885
US-20100330200-A1 COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT CXCR4, RARA, CXCL12 RARB 4/4885HDAC11 1919/4885HDAC2 3081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.