Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 10/20 | 0.56 |
| ▸ | NR0B2 | Q15466 | 4/20 | 0.56 |
| ▸ | RARB | P10826 | 4/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20018664 | 0.87 | PTPN11 (0.73) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL20122014 | 0.85 | RARB (0.72) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| Trifluoroacetic Acid SCHEMBL29462722 | 0.82 | PTPN11 (0.66) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL20018689 | 0.78 | HDAC11 (0.59) | PTPN11NR0B2RARBHDAC11HDAC4 | |
| SCHEMBL20122000 | 0.76 | RARB (0.56) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2393228 | 0.74 | PTPN11 (0.71) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2391204 | 0.74 | PTPN11 (0.77) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2391213 | 0.74 | PTPN11 (0.77) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL20018658 | 0.74 | PTPN11 (0.64) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2389152 | 0.73 | RARB (0.80) | PTPN11NR0B2RARBHDAC11HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3301085-A1 | RETINOID DERIVATIVES WITH ANTITUMOR ACTIVITY | BIOGEM S.CA.R.L. (IT) | 2018-04-04 | — | — | EP | disclosed |