Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 6/20 | 0.48 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | RARA | P10276 | 2/20 | 0.45 |
| ▸ | RARG | P13631 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20121991 | 0.87 | HDAC11 (0.48) | RARBPTPN11NR0B2HDAC11HDAC7 | |
| SCHEMBL20122014 | 0.86 | RARB (0.72) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL17916353 | 0.86 | RARB (0.50) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL17911574 | 0.86 | RARB (0.74) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL16517400 | 0.86 | RARB (0.74) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL20122021 | 0.80 | EPHX2 (0.50) | CYP26A1IDH1 | |
| SCHEMBL20018663 | 0.76 | PTPN11 (0.56) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL16516252 | 0.75 | HDAC11 (0.63) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL16516253 | 0.75 | HDAC11 (0.63) | RARBPTPN11NR0B2HDAC11HDAC3 | |
| SCHEMBL17916281 | 0.74 | HDAC11 (0.44) | RARBHDAC11HDAC7HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963439-B2 | Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-05-08 | — | — | US | disclosed |