Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 11/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122035 | 0.87 | EPHX2 (0.47) | EPHX2GSK3AGSK3BIDH1 | |
| SCHEMBL17916347 | 0.86 | EPHX2 (0.44) | EPHX2GSK3AGSK3BCYP26B1CYP26A1 | |
| SCHEMBL17911600 | 0.86 | EPHX2 (0.57) | EPHX2GSK3AGSK3BCYP26B1CYP26A1 | |
| SCHEMBL20122000 | 0.80 | RARB (0.56) | CYP26A1IDH1 | |
| SCHEMBL17911590 | 0.75 | EPHX2 (0.52) | EPHX2GSK3AGSK3B | |
| SCHEMBL17916358 | 0.74 | EPHX2 (0.42) | EPHX2GSK3AGSK3BIDH1 | |
| SCHEMBL16517420 | 0.72 | RARB (0.60) | EPHX2 | |
| SCHEMBL20122019 | 0.70 | EPHX2 (0.41) | EPHX2GSK3AGSK3B | |
| SCHEMBL5652618 | 0.69 | FFAR1 (0.63) | — | |
| SCHEMBL7796128 | 0.68 | CYP26B1 (0.52) | CYP26B1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963439-B2 | Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-05-08 | — | — | US | disclosed |