Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122472 | 0.87 | ALDH1A1 (0.42) | ACEMMEACE2ALDH1A1KDM4E | |
| SCHEMBL20122460 | 0.76 | ACE (0.51) | ACEMMEACE2ALDH1A1MAPT | |
| SCHEMBL20122456 | 0.76 | ACE (0.40) | ACEMMEACE2ALDH1A1KDM4E | |
| SCHEMBL20122455 | 0.73 | ACE (0.48) | ACEMMEACE2ALDH1A1KDM4E | |
| SCHEMBL11198946 | 0.72 | ACE (0.47) | ACEMMEACE2PPARGPPARA | |
| SCHEMBL16072791 | 0.72 | CES2 (0.47) | ALDH1A1MAPTRAB9AERCC5FEN1 | |
| SCHEMBL24359897 | 0.71 | ACE (0.51) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL9300940 | 0.71 | ACE (0.56) | ACEMMEACE2 | |
| SCHEMBL20122457 | 0.71 | ACE (0.46) | ACEMMEACE2 | |
| SCHEMBL11331818 | 0.69 | ACE (0.43) | ACEMMEACE2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963428-B1 | Bucillamine prodrugs, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2018-05-08 | — | — | US | disclosed |