Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122473 | 0.87 | MAPT (0.46) | ACEMMEACE2MAPTADAM17 | |
| SCHEMBL9630045 | 0.84 | MAPT (0.52) | MAPTADAM17KMT2AATMERCC5 | |
| SCHEMBL9630054 | 0.84 | MAPT (0.52) | MAPTADAM17KMT2AATMERCC5 | |
| SCHEMBL11385542 | 0.82 | KMT2A (0.53) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL11385539 | 0.82 | KMT2A (0.53) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL11384637 | 0.79 | KMT2A (0.50) | ACEMAPTADAM17KMT2AATM | |
| SCHEMBL11384632 | 0.79 | KMT2A (0.50) | ACEMAPTADAM17KMT2AATM | |
| SCHEMBL20122454 | 0.77 | MAPT (0.45) | ACEMMEACE2MAPTADAM17 | |
| SCHEMBL20122459 | 0.76 | ACE (0.51) | ACEMMEACE2MAPTKMT2A | |
| SCHEMBL20122512 | 0.74 | MAPT (0.34) | MAPTADAM17KMT2AATMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963428-B1 | Bucillamine prodrugs, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2018-05-08 | — | — | US | disclosed |