Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011511 | 0.90 | KDM4E (0.40) | KDM4EHTR2AHTR2CMMP2TSHR | |
| SCHEMBL2011259 | 0.87 | TAAR1 (0.43) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2015807 | 0.85 | MAPK14 (0.36) | KDM4EHTR2AHTR2CMMP2TSHR | |
| SCHEMBL2718191 | 0.79 | KDM4E (0.42) | KDM4EMMP2TSHRCYP3A4GMNN | |
| SCHEMBL2010638 | 0.76 | MAP4K4 (0.40) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2010932 | 0.76 | KDM4E (0.43) | KDM4EMMP2TSHRCYP3A4GMNN | |
| SCHEMBL2011836 | 0.76 | LMNA (0.40) | KDM4EHTR2AHTR2CMMP2TSHR | |
| SCHEMBL2014978 | 0.75 | KDM4E (0.46) | PIK3CDPDE4AKDM4EBCHEACHE | |
| SCHEMBL2012263 | 0.74 | PIK3CD (0.56) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2013295 | 0.74 | PIK3CD (0.53) | PIK3CDLMNAHTTSMN1; SMN2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |