Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30664211 | 0.89 | KDM4E (0.44) | KDM4ERPS6KA5ROCK2KDM5ADHODH | |
| SCHEMBL20122825 | 0.89 | KDM4E (0.44) | KDM4ERPS6KA5ROCK2KDM5ADHODH | |
| SCHEMBL20122794 | 0.75 | ROCK2 (0.41) | ROCK2KDM5AMETAP2CYP1A2CYP2C9 | |
| SCHEMBL30664295 | 0.75 | ROCK2 (0.41) | ROCK2KDM5AMETAP2CYP1A2CYP2C9 | |
| SCHEMBL20122823 | 0.73 | ROCK2 (0.38) | RPS6KA5ROCK2KDM5AMETAP2CYP1A2 | |
| SCHEMBL29756290 | 0.73 | ROCK2 (0.38) | RPS6KA5ROCK2KDM5AMETAP2CYP1A2 | |
| SCHEMBL20122870 | 0.73 | ROCK2 (0.43) | ROCK2KDM5AMETAP2CYP1A2CYP2C9 | |
| SCHEMBL30664279 | 0.73 | ROCK2 (0.43) | ROCK2KDM5AMETAP2CYP1A2CYP2C9 | |
| SCHEMBL20123045 | 0.72 | KDM4E (0.35) | KDM4ELMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30664293 | 0.71 | METAP2 (0.44) | ROCK2KDM5AMETAP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535263-B1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI SA (FR) | 2020-09-30 | — | — | EP | disclosed |
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |