Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27906790 | 0.89 | CHRM1 (0.38) | CD38WNT1DYRK1ASIGMAR1HRH3 | |
| SCHEMBL27906794 | 0.89 | CHRM1 (0.38) | CD38WNT1DYRK1ASIGMAR1HRH3 | |
| SCHEMBL17185039 | 0.88 | HTR4 (0.38) | POLBHSD17B10RIPK2SIGMAR1HTR4 | |
| SCHEMBL22208127 | 0.84 | POLB (0.46) | POLBHSD17B10SIGMAR1HRH3PDE7A | |
| SCHEMBL854472 | 0.84 | HTR4 (0.45) | POLBHSD17B10SIGMAR1HTR4HRH3 | |
| SCHEMBL23573288 | 0.81 | POLB (0.56) | POLBHSD17B10SIGMAR1HRH3ACKR3 | |
| SCHEMBL3369574 | 0.81 | POLB (0.51) | POLBHSD17B10SIGMAR1HRH3ACKR3 | |
| SCHEMBL22280239 | 0.80 | ALDH1A1 (0.54) | CD38SIGMAR1 | |
| SCHEMBL31428692 | 0.80 | TEAD1 (0.45) | CD38POLBHSD17B10WNT1DYRK1A | |
| SCHEMBL26854744 | 0.80 | SIGMAR1 (0.41) | CD38SIGMAR1ACKR3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513110-A1 | 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073263-A1 | 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |