Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.60 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015027 | 0.91 | HCRTR1 (0.56) | HCRTR1HCRTR2NPC1RAB9AOPRM1 | |
| SCHEMBL2013183 | 0.89 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2010539 | 0.88 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9AHPGD | |
| SCHEMBL2016643 | 0.87 | HCRTR1 (0.56) | HCRTR1HCRTR2NPC1RAB9AOPRM1 | |
| SCHEMBL2012310 | 0.86 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2014058 | 0.84 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL13139060 | 0.84 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL6918071 | 0.83 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2013516 | 0.83 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2016503 | 0.83 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |