Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27479660 | 0.91 | HSPB1 (0.53) | L3MBTL1HSPB1ALDH1A1MAPTTDP1 | |
| SCHEMBL27565180 | 0.85 | L3MBTL1 (0.50) | L3MBTL1HSPB1ALDH1A1MAPTTDP1 | |
| SCHEMBL4076795 | 0.84 | L3MBTL1 (0.51) | L3MBTL1HSPB1ALDH1A1MAPTTDP1 | |
| SCHEMBL27719773 | 0.84 | L3MBTL1 (0.48) | L3MBTL1HSPB1ALDH1A1MAPTTDP1 | |
| SCHEMBL11124304 | 0.83 | MAPT (0.48) | ALDH1A1MAPTTDP1KMT2ARAB9A | |
| SCHEMBL28406748 | 0.83 | HSPB1 (0.50) | L3MBTL1HSPB1MAPTTDP1ATM | |
| SCHEMBL10802204 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTTDP1KMT2ACYP3A4 | |
| SCHEMBL3475943 | 0.82 | TDP1 (0.43) | L3MBTL1HSPB1ALDH1A1MAPTTDP1 | |
| SCHEMBL8960306 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MAPTTDP1KMT2ARAB9A | |
| SCHEMBL27662020 | 0.81 | L3MBTL1 (0.49) | L3MBTL1HSPB1ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509954-A1 | 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072241-A1 | 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | WO | disclosed |