Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20014568 | 0.84 | NOTUM (0.39) | NOTUMHSD17B3CA1CA2CA4 | |
| SCHEMBL20014966 | 0.82 | NOTUM (0.40) | NOTUMHSD17B3 | |
| SCHEMBL20015254 | 0.82 | NOTUM (0.37) | NOTUMHTR2AHTR2CHSD17B3METAP1 | |
| SCHEMBL20123617 | 0.76 | HSD17B3 (0.32) | HSD17B3CA1CA2CA4CA6 | |
| SCHEMBL20014745 | 0.74 | HSD17B3 (0.43) | SLC6A2HTR2AHTR2CSLC6A4TRPA1 | |
| SCHEMBL20015251 | 0.74 | NOTUM (0.36) | NOTUM | |
| SCHEMBL20123623 | 0.74 | NOTUM (0.42) | NOTUM | |
| SCHEMBL10446736 | 0.72 | NOTUM (0.35) | NOTUMSLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL21183818 | 0.72 | NOTUM (0.33) | NOTUM | |
| SCHEMBL18350153 | 0.70 | TRPA1 (0.52) | SLC6A2HTR2AHTR2CSLC6A4TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |