Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20124089 | 0.81 | RAD52 (0.50) | TP53BCHEGNAI3GNAO1GNAI1 | |
| SCHEMBL11981725 | 0.81 | GNAI3 (0.36) | SMN1; SMN2USP2BCHEGNAI3GNAO1 | |
| SCHEMBL11048 | 0.81 | USP2 (0.39) | USP2ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL11960430 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2TP53USP2BCHEALDH1A1 | |
| SCHEMBL11981726 | 0.76 | SIGMAR1 (0.40) | SMN1; SMN2BCHEGNAI3GNAO1GNAI1 | |
| SCHEMBL20124153 | 0.75 | SIGMAR1 (0.39) | SMN1; SMN2USP2BCHEGNAI3GNAO1 | |
| SCHEMBL16687691 | 0.75 | SIGMAR1 (0.39) | SMN1; SMN2USP2BCHEGNAI3GNAO1 | |
| SCHEMBL15837589 | 0.75 | GBA1 (0.36) | BCHEGNAI3GNAO1GNAI1LMNA | |
| SCHEMBL2116367 | 0.75 | GBA1 (0.36) | BCHEGNAI3GNAO1GNAI1LMNA | |
| SCHEMBL14685578 | 0.74 | GNAI3 (0.43) | GNAI3GNAO1GNAI1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488532-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-05-09 | — | — | EP | disclosed |