Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16687691 | 1.00 | SIGMAR1 (0.39) | SIGMAR1MEN1CYP1A2KMT2ASMN1; SMN2 | |
| SCHEMBL11048 | 0.94 | USP2 (0.39) | MEN1KMT2ACARM1PRMT6PRMT1 | |
| SCHEMBL11050 | 0.86 | SIGMAR1 (0.46) | SIGMAR1HRH3BCHECARM1PRMT6 | |
| SCHEMBL20124090 | 0.86 | SIGMAR1 (0.46) | SIGMAR1HRH3BCHECARM1PRMT6 | |
| SCHEMBL11981726 | 0.83 | SIGMAR1 (0.40) | SIGMAR1MEN1CYP1A2KMT2ASMN1; SMN2 | |
| SCHEMBL11938 | 0.82 | SIGMAR1 (0.37) | SIGMAR1MEN1CYP1A2KMT2ASMN1; SMN2 | |
| SCHEMBL16687696 | 0.79 | L3MBTL1 (0.44) | SIGMAR1MEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL15760641 | 0.79 | SIGMAR1 (0.49) | SIGMAR1HRH3CARM1PRMT6PRMT1 | |
| SCHEMBL11981725 | 0.77 | GNAI3 (0.36) | SIGMAR1SMN1; SMN2BCHECARM1PRMT6 | |
| SCHEMBL11960430 | 0.75 | SMN1; SMN2 (0.37) | SIGMAR1MEN1CYP1A2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421476-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Melinta Therapeutics, Inc. (US) | 2019-01-02 | — | — | EP | disclosed |
| EP-2488532-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-05-09 | — | — | EP | disclosed |